N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide

Base Information

• Chemical Name: N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide
• CAS No.: 512827-90-6
• Molecular Formula: C₁₆H₂₄N₂O
• Molecular Weight: 260.379
• Mol file: 512827-90-6.mol

Synonyms:N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide

Chemical Property of N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide

There total 4 articles about N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-nitrobenzamide (512827-89-3) → N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide (512827-90-6)

Guidance literature:

With iron; acetic acid; In ethanol; water; for 5h; Heating;

DOI:10.1016/S0957-4166(02)00663-8

Reference yield:

(S)-1,2,2-trimethylpropylamine (3850-30-4,22526-47-2,59367-75-8,66228-31-7) → N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide (512827-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / toluene / 4 h / Heating

2: 63 percent / K₂CO₃; NaOH; n-Bu₄N(+)*HSO₄^(1-) / toluene / 6 h / 75 °C

3: 89 percent / iron powder; AcOH / H₂O; ethanol / 5 h / Heating

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; iron; potassium carbonate; acetic acid; In ethanol; water; toluene;

DOI:10.1016/S0957-4166(02)00663-8

Reference yield:

2-nitrobenzyl chloride (610-14-0) → N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-aminobenzamide (512827-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / toluene / 4 h / Heating

2: 63 percent / K₂CO₃; NaOH; n-Bu₄N(+)*HSO₄^(1-) / toluene / 6 h / 75 °C

3: 89 percent / iron powder; AcOH / H₂O; ethanol / 5 h / Heating

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; iron; potassium carbonate; acetic acid; In ethanol; water; toluene;

DOI:10.1016/S0957-4166(02)00663-8

upstream raw materials:

N-prop-2-enyl-N-[(2S)-3,3-dimethyl-2-butyl]-2-nitrobenzamide

(S)-1,2,2-trimethylpropylamine

2-nitrobenzyl chloride

N-[(2S)-3,3-dimethyl-2-butyl]-2-nitrobenzamide

Downstream raw materials:

N-allyl-2-azido-N-(1,2,2-trimethyl-propyl)-benzamide