6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

Base Information

Chemical Name:6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran
CAS No.:1563062-96-3
Molecular Formula:C₁₆H₈ClF₇S
Molecular Weight:400.747
Hs Code.:

Synonyms:6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

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Chemical Property of 6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

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Technology Process of 6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

There total 5 articles about 6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1563062-68-9
ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-(pentafluorophenyl)butan-2-yl}sulfanyl)methanethioate

: 1563062-96-3
6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

Guidance literature:: ethyl ({4-[(4-chlorophenyl)sulfanyl]-4,4-difluoro-1-(pentafluorophenyl)butan-2-yl}sulfanyl)methanethioate; In ethyl acetate; for 0.25h; Reflux; Inert atmosphere;

With dilauryl peroxide; In ethyl acetate; Inert atmosphere;
DOI:10.1021/ol5002939

Reference yield:

: 18803-44-6
sodium p-chlorothiophenolate

: 1563062-96-3
6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,4-dioxane / 4 h / Reflux; Inert atmosphere

2.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / Inert atmosphere

3.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

3.2: 12 h / Irradiation; Reflux; Inert atmosphere

4.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere

5.2: Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ol5002939

Reference yield:

: 16503-81-4
2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

: 1563062-96-3
6-chloro-2,2-difluoro-4-[(pentafluorophenyl)methyl]-3,4-dihydro-2H-1-benzothiopyran

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / Inert atmosphere

2.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

2.2: 12 h / Irradiation; Reflux; Inert atmosphere

3.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: ethyl acetate / 0.25 h / Reflux; Inert atmosphere

4.2: Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate;
DOI:10.1021/ol5002939