2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

Base Information

Chemical Name:2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester
CAS No.:467443-40-9
Molecular Formula:C₁₅H₁₅N₃O₇
Molecular Weight:349.3
Hs Code.:

Synonyms:2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

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Chemical Property of 2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

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Technology Process of 2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

There total 7 articles about 2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 79-37-8
oxalyl dichloride

: 2-[3-(3-nitro-benzyl)-ureido]-propionic acid ethyl ester

: 467443-40-9
2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 3h;
DOI:10.3797/scipharm.aut-01-204

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 467443-40-9
2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride

2: sodium azide / toluene / 1 h / Heating

3: 51 percent / sodium hydrogen carbonate / H₂O / 1 h / 0 °C

4: 93 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With thionyl chloride; sodium azide; sodium hydrogencarbonate; In tetrahydrofuran; water; toluene;
DOI:10.3797/scipharm.aut-01-204

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 467443-40-9
2-[3-(3-nitro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: AcOH; aq. NaOH

2: thionyl chloride

3: sodium azide / toluene / 1 h / Heating

4: 51 percent / sodium hydrogen carbonate / H₂O / 1 h / 0 °C

5: 93 percent / tetrahydrofuran / 3 h / 0 - 20 °C

With sodium hydroxide; thionyl chloride; sodium azide; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; water; toluene;
DOI:10.3797/scipharm.aut-01-204