1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Base Information

Chemical Name:1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate
CAS No.:1268383-82-9
Molecular Formula:C₃₁H₂₆F₅N₅O₃
Molecular Weight:611.571
Hs Code.:

Synonyms:1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

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Chemical Property of 1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

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Technology Process of 1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

There total 6 articles about 1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1268383-79-4
methyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

: 67-63-0,8013-70-5
isopropyl alcohol

: 1268383-82-9
1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: With potassium carbonate; at 100 ℃; for 0.166667h; Microwave;

Reference yield:

: 39891-13-9
2-(6-chloropyridin-3-yl)acetic acid

: 1268383-82-9
1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 20 °C

2.1: cesium fluoride / 1,2-dimethoxyethane / Inert atmosphere

2.2: 18 h / 20 °C / Inert atmosphere

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 21 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

5.1: potassium carbonate / 0.17 h / 100 °C / Microwave

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; cesium fluoride; In methanol; tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;

Reference yield:

: 717106-69-9
methyl 2-(6-chloropyridin-3-yl)acetate

: 1268383-82-9
1-methylethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{6-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-3-pyridinyl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: cesium fluoride / 1,2-dimethoxyethane / Inert atmosphere

1.2: 18 h / 20 °C / Inert atmosphere

2.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 21 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: potassium carbonate / 0.17 h / 100 °C / Microwave

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; cesium fluoride; In tetrachloromethane; 1,2-dimethoxyethane; N,N-dimethyl-formamide;