39891-13-9

Basic information

• Product Name: 2-CHLOROPYRIDINE-5-ACETIC ACID
• Synonyms: 2-CHLOROPYRIDINE-5-ACETIC ACID;(2-CHLOROPYRIDYL)-5-ACETIC ACID;(6-CHLORO-PYRIDIN-3-YL)-ACETIC ACID;6-CHLOROPYRIDINE-3-ACETIC ACID;2-Chloropyridin-5-ylacetic acid 95%;2-(6-CHLOROPYRIDIN-3-YL)ACETIC ACID;2-Chloropyridin-5-ylacetic acid;6-Chloro-3-pyridineacetic acid, 97%
• CAS NO: 39891-13-9
• Molecular Formula: C₇H₆ClNO₂
• Molecular Weight: 171.58
• EINECS: -0
• Product Categories: Pyridine;Pyridines;pyridine series
• Mol File: 39891-13-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 164-169°C
• Boiling Point: 336.613 °C at 760 mmHg
• Flash Point: 157.378 °C
• Appearance: /
• Density: 1.406 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.91±0.10(Predicted)
• CAS DataBase Reference: 2-CHLOROPYRIDINE-5-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROPYRIDINE-5-ACETIC ACID(39891-13-9)
• EPA Substance Registry System: 2-CHLOROPYRIDINE-5-ACETIC ACID(39891-13-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 39891-13-9(Hazardous Substances Data)

Usage

General Description

2-Chloropyridine-5-acetic acid is a chemical compound with the molecular formula C7H6ClNO2. It is a chlorinated derivative of pyridine and is often used as an intermediate in the production of agrochemicals, pharmaceuticals, and dyes. The compound is a white to slightly yellow crystalline powder that is slightly soluble in water and readily soluble in organic solvents. It is known for its ability to act as a building block for the synthesis of various heterocyclic compounds. Due to its versatile nature and usefulness in organic synthesis, 2-chloropyridine-5-acetic acid is a valuable chemical in the field of pharmaceutical and agrochemical research and development.

InChI:InChI=1/C7H6ClNO2/c8-6-2-1-5(4-9-6)3-7(10)11/h1-2,4H,3H2,(H,10,11)

Upstream product

• 39891-09-3 (6-chloro-pyridin-3-yl)-acetonitrile 
• 197376-47-9 ethyl (6-chloro-pyridin-3-yl)acetate 
• 53939-30-3 5-bromo-2-chloropyridine 
• 70258-18-3 2-chloro-5-(chloromethyl)pyridine 
• 124-38-9 carbon dioxide 

Downstream Products

• 897016-87-4 2-(6-Chloro-pyridin-3-yl)-N-(3-fluoro-benzyl)-acetamide 
• 1279713-24-4 aqua(tribenzyl)tin(IV) 6-chloro-3-pyridineacetate 
• 33252-28-7 6-chloronicotinonitrile 
• 174891-02-2 methyl 2-(6-aminopyridin-3-yl)acetate 
• 1260742-24-2 C₁₃H₁₈N₂O₄ 

Relevant articles and documents

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biological profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogues followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

COMPOUNDS USEFUL AS PESTICIDES

Compounds useful to control pests are provided.