C₁₇H₁₄O₅

Base Information

• Chemical Name: C₁₇H₁₄O₅
• CAS No.: 1370022-14-2
• Molecular Formula: C₁₇H₁₄O₅
• Molecular Weight: 298.295
• Mol file: 1370022-14-2.mol

Synonyms:C₁₇H₁₄O₅

Chemical Property of C₁₇H₁₄O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₇H₁₄O₅

There total 5 articles about C₁₇H₁₄O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-1H-isochromene-1,3(4H)-dione (4702-29-8) + benzaldehyde (100-52-7) → C17H14O5 (1370022-14-2)

Guidance literature:

With 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine; In tert-butyl methyl ether; at -15 ℃; for 164h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol300453s

Reference yield:

6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one (82735-28-2) → C17H14O5 (1370022-14-2)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; zinc / 2 h / 20 °C / Reflux

2: sulfuric acid / 2.33 h / 20 °C

3: thionyl chloride / dichloromethane / 3 h / Reflux

4: 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 164 h / -15 °C / Inert atmosphere

With thionyl chloride; sulfuric acid; 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In dichloromethane; tert-butyl methyl ether;

DOI:10.1021/ol300453s

Reference yield:

2-(β,β-dichloroethenyl)-5-methoxybenzoic acid (586415-11-4) → C17H14O5 (1370022-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 2.33 h / 20 °C

2: thionyl chloride / dichloromethane / 3 h / Reflux

3: 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine / tert-butyl methyl ether / 164 h / -15 °C / Inert atmosphere

With thionyl chloride; sulfuric acid; 3-[3,5-bis(trifluoromethyl)phenylamino]-4-[(S)-[6-methoxy-2-phenylquinolin-4-yl][(2S,4S,8R)-8-vinylquinuclidin-2-yl]methylamino]cyclobut-3-ene-1,2-dione; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl methyl ether;

DOI:10.1021/ol300453s

upstream raw materials:

7-methoxy-1H-isochromene-1,3(4H)-dione

benzaldehyde

6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one

2-(carboxymethyl)-5-methoxybenzoic acid

Downstream raw materials:

(3R,4R)-methyl 7-methoxy-1-oxo-3-phenylisochroman-4-carboxylate