{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

Base Information

Chemical Name:{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol
CAS No.:1330021-29-8
Molecular Formula:C₁₉H₁₆Cl₂F₃NO₂
Molecular Weight:418.243
Hs Code.:

Synonyms:{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

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Chemical Property of {4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

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Technology Process of {4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

There total 6 articles about {4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1330021-18-5
4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid ethyl ester

: 1330021-29-8
{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

Guidance literature:: 4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-benzoic acid ethyl ester; With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 60 ℃;

With hydrogenchloride; In tetrahydrofuran; methanol; diethyl ether; water;

Reference yield:

: 943437-03-4
1-(4-bromo-3-methylphenyl)-3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-en-1-one

: 1330021-29-8
{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 20 h / 120 °C / 45004.5 Torr

2: triethylamine / ethanol / 20 h / Reflux

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 60 °C

With methanol; sodium tetrahydroborate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol;

Reference yield:

: 3114-08-7
2-bromo-1-(4-bromo-3-methylphenyl)ethan-1-one

: 1330021-29-8
{4-[5-(3,5-Dichloro-phenyl)-2-methyl-5-trifluoromethyl-2,5-dihydro-isoxazol-3-yl]-2-methyl-phenyl}-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / 18 h / 20 °C

2: sodium hydrogencarbonate / dichloromethane; water

3: toluene / 3 h / Reflux

4: triethylamine / bis-triphenylphosphine-palladium(II) chloride / 20 h / 120 °C / 45004.5 Torr

5: triethylamine / ethanol / 20 h / Reflux

6: sodium tetrahydroborate; methanol / tetrahydrofuran / 60 °C

With methanol; sodium tetrahydroborate; sodium hydrogencarbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;