3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Base Information

Chemical Name:3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide
CAS No.:1378022-70-8
Molecular Formula:C₂₁H₂₀ClN₅O₂S
Molecular Weight:441.941
Hs Code.:

Synonyms:3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Suppliers and Price of 3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

There total 7 articles about 3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377581-88-8
4-Isopropoxy-3-thioureido-benzamide

: 2-bromo-1-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)ethanone hydrobromide

: 1378022-70-8
3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Guidance literature:: 4-Isopropoxy-3-thioureido-benzamide; 2-bromo-1-(6-chloro-2-methylimidazo[1,2-a]pyridin-3-yl)ethanone hydrobromide; In ethanol; at 20 ℃; for 24h;

With ammonia; In methanol; ethanol;

Reference yield:

: 349-02-0
4-fluoro-3-nitrobenzamide

: 1378022-70-8
3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 5 h / 0 - 23 °C

2.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1 h / 0 - 23 °C

2.2: 0 °C

3.1: sodium carbonate / chloroform; water / 3.17 h / 20 °C

4.1: ammonia / methanol / 16 h / 20 °C

5.1: ethanol / 24 h / 20 °C

With methanol; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ammonia; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water; toluene;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1378022-70-8
3-[4-(6-Chloro-2-methyl-imidazo[1,2-a]pyridin-3-yl)-thiazol-2-ylamino]-4-isopropoxy-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / water / 3 h / 80 °C

1.2: 0.58 h / 0 °C / Cooling with ice

2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 5 h / 0 - 23 °C

3.1: sodium tetrahydroborate; methanol; nickel(II) chloride hexahydrate / 1 h / 0 - 23 °C

3.2: 0 °C

4.1: sodium carbonate / chloroform; water / 3.17 h / 20 °C

5.1: ammonia / methanol / 16 h / 20 °C

6.1: ethanol / 24 h / 20 °C

With methanol; sodium tetrahydroborate; thionyl chloride; nickel(II) chloride hexahydrate; ammonia; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; ethanol; chloroform; water; toluene;