1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

Base Information

Chemical Name:1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide
CAS No.:911717-57-2
Molecular Formula:C₂₂H₂₈BrN₃O₂
Molecular Weight:446.387
Hs Code.:

Synonyms:1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

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Chemical Property of 1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

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Technology Process of 1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

There total 3 articles about 1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 757976-23-1
1-[(3-bromophenyl)amino]cyclohexanecarboxylic acid

: 24455-93-4
N-(4-methoxyphenyl)ethane-1,2-diamine

: 911717-57-2
1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 10h;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 108-36-1
1,3-dibromobenzene

: 911717-57-2
1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / K₂CO₃; CuBr*Me₂S / N,N-dimethyl-acetamide / 3 h / 120 °C

2: 73 percent / 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide / 10 h

With copper(I) bromide dimethylsulfide complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.031

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 911717-57-2
1-[(3-bromophenyl)amino]-N-{2-[(4-methoxyphenyl)amino]ethyl}cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / K₂CO₃; CuBr*Me₂S / N,N-dimethyl-acetamide / 3 h / 120 °C

2: 73 percent / 1-hydroxy-1H-benzotriazole; 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide HCl / dimethylformamide / 10 h

With copper(I) bromide dimethylsulfide complex; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.031