757976-23-1Relevant academic research and scientific papers
Aromatic amines as nucleophiles in the Bargellini reaction
Butcher, Ken J.,Hurst, Jenny
experimental part, p. 2497 - 2500 (2009/09/05)
Aromatic amines can be employed in the Bargellini reaction to generate useful intermediates. Rapid, practical access to functionalised, privileged structures may have significant utility in the synthesis of drug-like molecules. An improved synthesis of carfentanil analogues illustrates this point.
Arylamine based cathepsin K inhibitors: Investigating P3 heterocyclic substituents
Shinozuka, Tsuyoshi,Shimada, Kousei,Matsui, Satoshi,Yamane, Takahiro,Ama, Mayumi,Fukuda, Takeshi,Taki, Motohiko,Takeda, Yuko,Otsuka, Eri,Yamato, Michiko,Naito, Satoru
, p. 6807 - 6819 (2007/10/03)
A modification of novel cathepsin K inhibitors I was carried out. The structural design was aimed at reducing the lipophilic character of compounds I for obtaining better pharmacokinetic profiles. This modification afforded several less lipophilic compoun
