tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

Base Information

Chemical Name:tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate
CAS No.:1403257-63-5
Molecular Formula:C₂₈H₃₉BrN₄O₄
Molecular Weight:575.546
Hs Code.:

Synonyms:tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

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Chemical Property of tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

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Technology Process of tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

There total 7 articles about tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1403257-64-6
C₂₀H₂₉BrN₂O₄

: 1403257-63-5
tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₂₀H₂₉BrN₂O₄; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide;

Reference yield:

: 107650-20-4
5-bromo-2-methyl-3-nitro-benzoic acid

: 1403257-63-5
tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

3.1: acetic acid / methanol / 8 h / 20 °C

3.2: 0 °C

4.1: caesium carbonate / acetonitrile / 7 h / 80 °C

5.1: sodium hydroxide; water / methanol / 1 h / 60 °C

5.2: pH 4 - 6

6.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; iron; sodium carbonate; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 220514-28-3
5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

: 1403257-63-5
tert-butyl ((1S,4S)-4-((5-bromo-3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methylphenyl)(methyl)amino)cyclohexyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C

2.1: acetic acid / methanol / 8 h / 20 °C

2.2: 0 °C

3.1: caesium carbonate / acetonitrile / 7 h / 80 °C

4.1: sodium hydroxide; water / methanol / 1 h / 60 °C

4.2: pH 4 - 6

5.1: dimethyl sulfoxide / 0.25 h / 20 °C

With water; iron; ammonium chloride; caesium carbonate; acetic acid; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; acetonitrile;