1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

Base Information

Chemical Name:1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone
CAS No.:1005402-55-0
Molecular Formula:C₂₁H₂₆N₂O₂
Molecular Weight:338.45
Hs Code.:

Synonyms:1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

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Chemical Property of 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

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Technology Process of 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

There total 3 articles about 1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 109-06-8
α-picoline

: 1005402-54-9
4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-benzoic acid ethyl ester

: 1005402-55-0
1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 45 ℃;
DOI:10.1016/j.bmcl.2011.06.108

Reference yield:

: 120-47-8
Ethyl 4-hydroxybenzoate

: 1005402-55-0
1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 80 °C

2: potassium carbonate; sodium iodide / acetonitrile / 80 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 45 °C

With potassium carbonate; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.108

Reference yield:

: 75912-94-6
4-(3-chloropropoxy)benzoic acid ethyl ester

: 1005402-55-0
1-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-pyridin-2-yl-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetonitrile / 80 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 45 °C

With potassium carbonate; sodium iodide; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmcl.2011.06.108