[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

Base Information

Chemical Name:[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide
CAS No.:852332-94-6
Molecular Formula:C₂₇H₃₃NO₂S₃
Molecular Weight:499.763
Hs Code.:

Synonyms:[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

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Chemical Property of [1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

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Technology Process of [1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

There total 3 articles about [1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 852332-84-4
(S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene

: 190448-86-3
4-Methyl-benzenesulfinic acid (S)-pent-(E)-ylideneamide

: 852332-94-6
[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

Guidance literature:: (S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

4-Methyl-benzenesulfinic acid (S)-pent-(E)-ylideneamide; In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1080/10426500590913320

Reference yield: 65.0%

: 852332-84-4
(S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene

: 153277-55-5
(S)-(+)-N-pentylidene-p-toluenesulfinamide

: 852332-94-6
[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

Guidance literature:: (S)-α-(methylsulfenyl)-2-(p-tolylsulfinyl)toluene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

(S)-(+)-N-pentylidene-p-toluenesulfinamide; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1021/jo050129x

Reference yield:

: 10381-68-7,42872-16-2,78821-95-1,1517-78-8
(S)-2-methyl-1-(p-tolylsulfinyl)benzene

: 852332-94-6
[1R,2S,(S)S]-N-{1-butyl-2-[(S)-2-(p-toluenesulfinyl)phenyl]-2-(methylthio)ethyl}-p-toluenesulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / -78 °C

1.2: 70 percent / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.1: LDA / tetrahydrofuran; hexane / 0.08 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/jo050129x