Technology Process of 7-(2,4-Difluoro-benzenesulfonylamino)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid hydroxyamide
There total 7 articles about 7-(2,4-Difluoro-benzenesulfonylamino)-5,6,7,8-tetrahydro-naphthalene-2-carboxylic acid hydroxyamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine; potassium hydroxide;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium cyanoborohydride; ammonium acetate / methanol / 20 °C
2: triethylamine / ethanol / 2 h / 20 °C
3: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C
4: hydrogenchloride; methanol / 1 h / 20 °C
5: triethylamine / dichloromethane
6: potassium hydroxide; hydroxylamine / water
With
hydrogenchloride; methanol; 1,3-bis-(diphenylphosphino)propane; ammonium acetate; hydroxylamine; sodium cyanoborohydride; triethylamine; potassium hydroxide;
palladium diacetate;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C
2: hydrogenchloride; methanol / 1 h / 20 °C
3: triethylamine / dichloromethane
4: potassium hydroxide; hydroxylamine / water
With
hydrogenchloride; methanol; 1,3-bis-(diphenylphosphino)propane; hydroxylamine; triethylamine; potassium hydroxide;
palladium diacetate;
In
dichloromethane; water; N,N-dimethyl-formamide;
