3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid

Base Information

• Chemical Name: 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid
• CAS No.: 1150263-50-5
• Molecular Formula: C₁₅H₁₄ClNO₃
• Molecular Weight: 291.734
• Mol file: 1150263-50-5.mol

Synonyms:3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid

Chemical Property of 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid

There total 6 articles about 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

methyl 3-(5-chloropyridin-2-yl)-5-isopropenylbenzoate (1150263-45-8) → 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid (1150263-50-5)

Guidance literature:

methyl 3-(5-chloropyridin-2-yl)-5-isopropenylbenzoate; With water; sodium hydroxide; In methanol;

With methanesulfonic acid; water;

DOI:10.1016/j.bmcl.2018.02.039

Reference yield:

3-(5-chloropyridin-2-yl)-5-isopropenylbenzoic acid (1150263-47-0) → 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid (1150263-50-5)

Guidance literature:

3-(5-chloropyridin-2-yl)-5-isopropenylbenzoic acid; With methanesulfonic acid; water; at 50 ℃; for 18h;

With water; sodium carbonate; at 20 ℃; pH=3 - 4;

Reference yield:

methyl 3-bromo-5-iodobenzoate (188813-07-2) → 3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)benzoic acid (1150263-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate; copper(l) chloride; palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl-formamide / 80 °C

2: palladium diacetate; trisodium tris(3-sulfophenyl)phosphine; diisopropylamine / N,N-dimethyl-formamide; water / 80 °C

3: water; sodium hydroxide / methanol

With 1,1'-bis-(diphenylphosphino)ferrocene; trisodium tris(3-sulfophenyl)phosphine; water; palladium diacetate; caesium carbonate; diisopropylamine; copper(l) chloride; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2018.02.039

upstream raw materials:

3-(5-chloropyridin-2-yl)-5-isopropenylbenzoic acid

methyl 3-bromo-5-iodobenzoate

methyl 3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

3-bromo-5-(5-chloro-pyridin-2-yl)-benzoic acid methyl ester

Downstream raw materials:

3-(5-chloropyridin-2-yl)-5-(1-hydroxy-1-methylethyl)-N-{(1R)-1-[1-oxido-6-(trifluoromethyl)pyridin-3-yl]ethyl}benzamide