meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal

Base Information

• Chemical Name: meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal
• CAS No.: 244153-90-0
• Molecular Formula: C₁₅H₂₃NO₈
• Molecular Weight: 345.35

Synonyms:meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal

Chemical Property of meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal

There total 2 articles about meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

acetyl chloride (75-36-5) + meso-(1r,2R,6S)-1-nitrocyclohexane-2,6-diol-1-acetaldehyde 1,3-propanediol acetal (244153-85-3) → meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal (244153-90-0)

Guidance literature:

With dmap; In dichloromethane; for 2h;

DOI:10.1021/jo990293i

Reference yield:

2-(2-nitroethyl)-1,3-dioxane (146073-16-7) → meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal (244153-90-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / 1,1,3,3-tetramethylguanidine / tetrahydrofuran

2: 81 percent / DMAP / CH₂Cl₂ / 2 h

With dmap; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dichloromethane; 1: tandem Henry condensation / 2: Acetylation;

DOI:10.1021/jo990293i

Reference yield:

meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal (244153-90-0) → Acetic acid (1S,2R,3R)-3-acetoxy-2-amino-2-[1,3]dioxan-2-ylmethyl-cyclohexyl ester

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; at 60 ℃; for 14h; under 760 Torr;

DOI:10.1021/jo990293i

upstream raw materials:

acetyl chloride

meso-(1r,2R,6S)-1-nitrocyclohexane-2,6-diol-1-acetaldehyde 1,3-propanediol acetal

2-(2-nitroethyl)-1,3-dioxane

Downstream raw materials:

4-((1R,2R,6S)-1-Amino-2,6-dihydroxy-cyclohexyl)-butyric acid

meso-(1r,2R,6S)-1-acetamido-2,6-diacetoxycyclohexane-1-acetaldehyde 1,3-propanediol acetal

(-)-(6S,12S)-12-phenoxythionocarbonyloxy-7-aza-1,4-dioxadispiro[4,0,5,4]pentadecan-8-one

meso-(E)-(1r,2R,6S)-1-acetamido-2,6-diacetoxycyclohexanebutanoic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 244153-90-0 meso-(1r,2R,6S)-2,6-diacetoxy-1-nitrocyclohexane-1-acetaldehyde 1,3-propanediol acetal

Send

Send

Metric Ton KG G Pound L ML

Send

Send