6-broMo-1,2-diMethyl-1H-1,3-benzodiazole

Base Information

• Chemical Name: 6-broMo-1,2-diMethyl-1H-1,3-benzodiazole
• CAS No.: 99512-64-8
• Molecular Formula: C₉H₉BrN₂
• Molecular Weight: 225.088
• Mol file: 99512-64-8.mol

Synonyms:6-bromo-1,2-dimethyl-1H-benzo[d]imidazole

Chemical Property of 6-broMo-1,2-diMethyl-1H-1,3-benzodiazole

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-1,2-dimethyl-1H-benzo[d]imidazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-broMo-1,2-diMethyl-1H-1,3-benzodiazole

There total 1 articles about 6-broMo-1,2-diMethyl-1H-1,3-benzodiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-2-fluoronitrobenzene (321-23-3) → 6-bromo-1,2-dimethyl-1H-benzo[d]imidazole (99512-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide; tetrahydrofuran / 20 °C

2: hydrogen / tetrahydrofuran / 20 °C / 2585.81 Torr

3: 2 h / 130 °C

With hydrogen; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 43.0%

6-bromo-1,2-dimethyl-1H-benzo[d]imidazole (99512-64-8) + 1-(4-(methoxy-d3)phenyl)-5-methyl-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one → 3-(1,2-dimethyl-1H-benzo[d]imidazol-6-yl)-1-(4-(methoxy-d3)phenyl)-5-methyl-7-(methylthio)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

Guidance literature:

With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; In acetonitrile; at 100 ℃; for 14h;

Reference yield:

6-bromo-1,2-dimethyl-1H-benzo[d]imidazole (99512-64-8) + carbon monoxide (201230-82-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate (1038387-93-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In methanol; at 80 ℃; for 18h;

DOI:10.1016/j.bmcl.2019.126812

upstream raw materials:

4-bromo-2-fluoronitrobenzene

Downstream raw materials:

methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate

Refernces

• 1、 Igawa, Hideyuki,Takahashi, Masashi,Shirasaki, Mikio,Kakegawa, Keiko,Kina, Asato,Ikoma, Minoru,Aida, Jumpei,Yasuma, Tsuneo,Okuda, Shoki,Kawata, Yayoi,Noguchi, Toshihiro,Yamamoto, Syunsuke,Fujioka, Yasushi,Kundu, Mrinalkanti,Khamrai, Uttam,Nakayama, Masaharu,Nagisa, Yasutaka,Kasai, Shizuo,Maekawa, Tsuyoshi. "Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition". . p. 2486 - 2503. Retrieved 2016/05/09.