Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate

Base Information

• Chemical Name: Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate
• CAS No.: 1038387-93-7
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.228
• Hs Code.: 2933990090
• Mol file: 1038387-93-7.mol

Synonyms:Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate

Chemical Property of Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate

Chemical Property:

• Boiling Point: 364.2±15.0 °C(Predicted)
• PSA: 44.12000
• Density: 1.20±0.1 g/cm3(Predicted)
• LogP: 1.66830

Purity/Quality:

98% ^*data from raw suppliers

Methyl1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate

There total 4 articles about Methyl 1,2-dimethyl-1H-benzo[d]imidazole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.83%

methyl 4-amino-3-(methylamino)benzoate (616224-38-5) + acetic acid (64-19-7,77671-22-8) → methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate (1038387-93-7)

Guidance literature:

With hydrogenchloride; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.10.011

Reference yield:

4-amino-3-(methylamino)benzoic acid (66630-74-8) + acetic acid (64-19-7,77671-22-8) + diazomethyl-trimethyl-silane (18107-18-1) → methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate (1038387-93-7)

Guidance literature:

4-amino-3-(methylamino)benzoic acid; acetic acid; Heating / reflux;

diazomethyl-trimethyl-silane; In hexanes; metahnol; acetonitrile; at 0 ℃; for 1h;

Reference yield:

6-bromo-1,2-dimethyl-1H-benzo[d]imidazole (99512-64-8) + carbon monoxide (201230-82-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 1,2-dimethyl-1H-benzimidazole-6-carboxylate (1038387-93-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In methanol; at 80 ℃; for 18h;

DOI:10.1016/j.bmcl.2019.126812

upstream raw materials:

4-amino-3-(methylamino)benzoic acid

acetic acid

diazomethyl-trimethyl-silane

methyl 4-amino-3-(methylamino)benzoate

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