methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

Base Information

Chemical Name:methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate
CAS No.:873581-24-9
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

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Chemical Property of methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

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Technology Process of methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

There total 5 articles about methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 684283-02-1
methyl 2-(benzyloxycarbonylamino)-2-(1,4-dioxaspiro[4.5]decan-8-ylidene)acetate

: 873581-24-9
methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

Guidance literature:: With hydrogen; [(S,S)-Me-BPE-Rh(COD)]+OTf-; In methanol; for 32h; under 3620.13 Torr; Product distribution / selectivity; Parr reactor;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 873581-24-9
methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / ethyl acetate / 72 h / 20 °C

2: hydrogen / (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 72 h / 20 °C / 3620.13 Torr

With hydrogen; N,N,N',N'-tetramethylguanidine; (-)-bis((2S,5S)-2,5-dimethylphospholano)ethane(cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; ethyl acetate;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 100945-15-1,88568-95-0
N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester

: 873581-24-9
methyl (2S)-{[(benzyloxy)carbonyl]amino}(1,4-dioxaspiro[4.5]dec-8-yl)ethanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N,N',N'-tetramethylguanidine / ethyl acetate / 72 h / 20 °C

2: hydrogen / 1,2-bis[(2S,5S)-2,5-(dimethylphospholano)]-ethane-(cyclooctadiene)rhodium(I) tetrafluoroborate / methanol / 72 h / 20 °C / 3620.13 Torr

With hydrogen; N,N,N',N'-tetramethylguanidine; 1,2-bis[(2S,5S)-2,5-(dimethylphospholano)]-ethane-(cyclooctadiene)rhodium(I) tetrafluoroborate; In methanol; ethyl acetate;