(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Base Information

Chemical Name:(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol
CAS No.:204120-98-9
Molecular Formula:C₃₆H₆₀O₆Si₂
Molecular Weight:645.04
Hs Code.:

(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Synonyms:(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

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Chemical Property of (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

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Technology Process of (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

There total 4 articles about (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 204120-94-5
2,2-Dimethyl-propionic acid (3R,4R)-3-(tert-butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyl ester

: 204120-98-9
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 0.5h;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 196861-58-2
2,2-Dimethyl-propionic acid (R)-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyl ester

: 204120-98-9
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi; 3.) Ac₂O, DMAP; 4.) 6percent HgNa / 1.) THF, hexane, -78 deg C, 45 min; 2.) THF, hexane, -78 deg C, 1 h; 3.) r.t., 4 h; 4.) MeOH, AcOEt, -50 deg C, 6 h

2: 1.) OsO₄, NMO; 2.) PPTS / 1.) acetone, water, r.t., 2 h; 2.) MeOH, CH₂Cl₂, r.t., 2 d

3: 81 percent / NaH / dimethylformamide / Ambient temperature

4: 96 percent / DIBAH / CH₂Cl₂; hexane / 0.5 h / -78 °C

With dmap; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium amalgam; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 204120-85-4
2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

: 204120-98-9
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) OsO₄, NMO; 2.) PPTS / 1.) acetone, water, r.t., 2 h; 2.) MeOH, CH₂Cl₂, r.t., 2 d

2: 81 percent / NaH / dimethylformamide / Ambient temperature

3: 96 percent / DIBAH / CH₂Cl₂; hexane / 0.5 h / -78 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10758-4