2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester
CAS No.:204120-85-4
Molecular Formula:C₄₁H₆₈O₆Si₂
Molecular Weight:713.158
Hs Code.:

2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

There total 1 articles about 2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191660-22-7
((2R,4R)-4-Benzenesulfonylmethyl-6,6-dimethoxy-2-methyl-hexyloxy)-tert-butyl-diphenyl-silane

: 196861-58-2
2,2-Dimethyl-propionic acid (R)-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyl ester

: 204120-85-4
2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

: (E)-(3R,6R)-8,8-Dimethoxy-3-(4-methoxy-benzyloxy)-6-methyl-oct-4-enoic acid tert-butyl ester

Guidance literature:: With dmap; n-butyllithium; sodium amalgam; acetic anhydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, hexane, -78 deg C, 45 min; 2.) THF, hexane, -78 deg C, 1 h; 3.) r.t., 4 h; 4.) MeOH, AcOEt, -50 deg C, 6 h;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 204120-85-4
2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

: 204120-98-9
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) OsO₄, NMO; 2.) PPTS / 1.) acetone, water, r.t., 2 h; 2.) MeOH, CH₂Cl₂, r.t., 2 d

2: 81 percent / NaH / dimethylformamide / Ambient temperature

3: 96 percent / DIBAH / CH₂Cl₂; hexane / 0.5 h / -78 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 204120-85-4
2,2-Dimethyl-propionic acid (E)-(3R,6R,8R)-3-(tert-butyl-dimethyl-silanyloxy)-9-(tert-butyl-diphenyl-silanyloxy)-6-(2,2-dimethoxy-ethyl)-8-methyl-non-4-enyl ester

: 204120-99-0
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) OsO₄, NMO; 2.) PPTS / 1.) acetone, water, r.t., 2 h; 2.) MeOH, CH₂Cl₂, r.t., 2 d

2: 81 percent / NaH / dimethylformamide / Ambient temperature

3: 96 percent / DIBAH / CH₂Cl₂; hexane / 0.5 h / -78 °C

4: 76 percent / (COCl)2, DMSO, Huenig base / CH₂Cl₂ / 2 h / -78 - -20 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; oxalyl dichloride; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(97)10758-4