(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

Base Information

Chemical Name:(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid
CAS No.:204120-87-6
Molecular Formula:C₃₆H₅₈O₇Si₂
Molecular Weight:659.023
Hs Code.:

(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

Synonyms:(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

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Chemical Property of (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

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Technology Process of (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

There total 6 articles about (3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 204120-99-0
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyraldehyde

: 204120-87-6
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

Guidance literature:: With potassium permanganate; potassium dihydrogenphosphate; In water; tert-butyl alcohol; at 0 ℃; for 0.25h;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 196861-58-2
2,2-Dimethyl-propionic acid (R)-3-(tert-butyl-dimethyl-silanyloxy)-4-oxo-butyl ester

: 204120-87-6
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi; 3.) Ac₂O, DMAP; 4.) 6percent HgNa / 1.) THF, hexane, -78 deg C, 45 min; 2.) THF, hexane, -78 deg C, 1 h; 3.) r.t., 4 h; 4.) MeOH, AcOEt, -50 deg C, 6 h

2: 1.) OsO₄, NMO; 2.) PPTS / 1.) acetone, water, r.t., 2 h; 2.) MeOH, CH₂Cl₂, r.t., 2 d

3: 81 percent / NaH / dimethylformamide / Ambient temperature

4: 96 percent / DIBAH / CH₂Cl₂; hexane / 0.5 h / -78 °C

5: 76 percent / (COCl)2, DMSO, Huenig base / CH₂Cl₂ / 2 h / -78 - -20 °C

6: 100 percent / KMnO₄, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.25 h / 0 °C

With dmap; potassium permanganate; potassium dihydrogenphosphate; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; sodium amalgam; oxalyl dichloride; pyridinium p-toluenesulfonate; acetic anhydride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)10758-4

Reference yield:

: 204120-98-9
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butan-1-ol

: 204120-87-6
(3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-4-{(2S,3R,5S)-3-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-5-methoxy-tetrahydro-furan-2-yl}-4-methoxy-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / (COCl)2, DMSO, Huenig base / CH₂Cl₂ / 2 h / -78 - -20 °C

2: 100 percent / KMnO₄, KH₂PO₄ / 2-methyl-propan-2-ol; H₂O / 0.25 h / 0 °C

With potassium permanganate; potassium dihydrogenphosphate; oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(97)10758-4