Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate

Base Information

Chemical Name:Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate
CAS No.:185629-62-3
Molecular Formula:C₁₂H₁₅Cl₂NO₃
Molecular Weight:292.162
Hs Code.:
DSSTox Substance ID:DTXSID901227105

Synonyms:Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate;DTXSID901227105;185629-62-3

Suppliers and Price of Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:291.0428987
Heavy Atom Count:18
Complexity:266

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(C(=CC(=C1)Cl)N)OCCCCl

Technology Process of Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate

There total 2 articles about Ethyl 3-amino-5-chloro-2-(3-chloropropoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 185629-61-2
3-Acetylamino-5-chloro-2-(3-hydroxy-propoxy)-benzoic acid ethyl ester

: 185629-62-3
3-Amino-5-chloro-2-(3-chloro-propoxy)-benzoic acid ethyl ester

Guidance literature:: With thionyl chloride; N,N-dimethyl-formamide; for 10h; Heating;
DOI:10.1248/cpb.44.2051

Reference yield:

: 139329-90-1
N-(3-ethoxycarbonyl-5-chloro-2-hydroxyphenyl)acetamide

: 185629-62-3
3-Amino-5-chloro-2-(3-chloro-propoxy)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / K₂CO₃ / dimethylformamide / 4 h / 70 - 75 °C

2: 60 percent / SOCl₂, DMF / 10 h / Heating

With thionyl chloride; potassium carbonate; N,N-dimethyl-formamide; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.2051