4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

Base Information

Chemical Name:4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride
CAS No.:186519-63-1
Molecular Formula:C₁₆H₁₂N₄O₂*ClH
Molecular Weight:328.758
Hs Code.:

Synonyms:4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

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Technology Process of 4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

There total 2 articles about 4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 79-37-8
oxalyl dichloride

: 186519-60-8
4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid

: 186519-63-1
4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

Guidance literature:: In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 22276-95-5
5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 186519-63-1
4-(3-ethynyl-phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-5-carboxylic acid methyl esterhydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran; CO₂; water

2: methanol

3: methanol; dichloromethane; N,N-dimethyl-formamide; acetone

With n-butyllithium; In tetrahydrofuran; methanol; CO₂; dichloromethane; water; N,N-dimethyl-formamide; acetone;