Noramidopyrine

Base Information

• Chemical Name: Noramidopyrine
• CAS No.: 519-98-2
• Molecular Formula: C12H15 N3 O
• Molecular Weight: 217.271
• Hs Code.: 2933199090
• European Community (EC) Number: 208-281-3
• UNII: NER31DE951
• DSSTox Substance ID: DTXSID80199865
• Nikkaji Number: J25.268I
• Wikidata: Q27140411
• Metabolomics Workbench ID: 66330
• ChEMBL ID: CHEMBL1164701
• Mol file: 519-98-2.mol

Synonyms:methylaminoantipyrine;monomethylaminoantipyrine;noramidopyrine;noramidopyrine mesylate, sodium salt;noraminopyrine

Chemical Property of Noramidopyrine

Chemical Property:

• Vapor Pressure: 0.000245mmHg at 25°C
• Melting Point: 50-53°C
• Boiling Point: 324.5°C at 760 mmHg
• PKA: 4.76±0.20(Predicted)
• Flash Point: 150°C
• PSA: 38.96000
• Density: 1.20±0.1 g/cm3 (20 ºC 760 Torr)
• LogP: 2.40110
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 217.121512110
• Heavy Atom Count: 16
• Complexity: 318

Purity/Quality:

99% ^*data from raw suppliers

4-Methylamino Antipyrine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=O)N(N1C)C2=CC=CC=C2)NC
• Uses: A metabolite of Dipyrone

Technology Process of Noramidopyrine

There total 22 articles about Noramidopyrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl-)-N-methyl-carbamidsaeuremethylester (10116-07-1) → 4-methylaminoantipyrine (519-98-2)

Guidance literature:

With potassium hydroxide; at 50 ℃;

Reference yield: 89.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + carbonic acid dimethyl ester (616-38-6) → 4-methylaminoantipyrine (519-98-2)

Guidance literature:

With 1-butyl-3-methylimidazolium Tetrafluoroborate; at 160 ℃; for 5h; Temperature; Concentration;

Reference yield: 86.7%

metamizol (68-89-3) → 4-methylaminoantipyrine (519-98-2)

Guidance literature:

With hydrogenchloride; In methanol; water; at 60 ℃; for 3h;

DOI:10.1002/ddr.21083

upstream raw materials:

formaldehyd

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

aminopyrine

N-(phenylmethylene)-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

Downstream raw materials:

2-bromo-propionic acid-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-methyl-amide]

(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-methyl-carbamoyl chloride

N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-N-methyl-glycine nitrile

aminopyrine

Refernces

• 1、 Yoshioka,Ogata,Shibazaki,Ejima. "Stability of sulpyrine. III. Copper(II) ion catalyzed oxidation by molecular oxygen". . p. 2723 - 2728. Retrieved 1978.
• 2、 Bacil, Raphael P.,Buoro, Rafael M.,Campos, Othon S.,Ramos, Matesa A.,Sanz, Caroline G.,Serrano, Silvia H.P.. "Electrochemical behaviour of dipyrone (metamizole) and others pyrazolones". . p. 358 - 366. Retrieved 2018.
• 3、 Lopez-Munoz, Francisco Javier,Soria-Arteche, Olivia,Lopez, Jose Raul Medina,Hurtado Y De La Pena, Marcela,Garcia, Ma. Concepcion Lozada,Moreno-Rocha, Luis Alfonso,Dominguez-Ramirez, Adriana Miriam. "Antinociceptive activity of metamizol metabolites in a rat model of arthritic pain". . p. 332 - 338. Retrieved 2013/08/23.