N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

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Chemical Name:N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide
CAS No.:1366088-52-9
Molecular Formula:C₄₅H₄₀F₃N₅O₆
Molecular Weight:803.838
Hs Code.:

Synonyms:N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

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Chemical Property of N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

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Technology Process of N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

There total 6 articles about N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 931-53-3
Cyclohexyl isocyanide

: 104-03-0
4-nitrobenzeneacetic acid

: 1366088-23-4
3-benzyl-5-(m-aminophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione

: 100-52-7
benzaldehyde

: 1366088-52-9
N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

Guidance literature:: 3-benzyl-5-(m-aminophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione; benzaldehyde; In methanol; for 0.5h; Reflux;

Cyclohexyl isocyanide; 4-nitrobenzeneacetic acid; In methanol; Reflux;
DOI:10.1016/j.tet.2012.01.073

Reference yield:

: 1366087-99-1
N-benzyl-2-[N-(3-trifluoromethylphenyl)-N-(trichloroacetyl)amino]-2-(m-nitrophenyl)acetamide

: 1366088-52-9
N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / methanol / 0.08 h

2.1: iron; acetic acid / 0.5 h / 50 - 60 °C

3.1: methanol / 0.5 h / Reflux

3.2: Reflux

With sodium ethanolate; iron; acetic acid; In methanol; 3.1: Ugi condensation / 3.2: Ugi condensation;
DOI:10.1016/j.tet.2012.01.073

Reference yield:

: 1366088-11-0
3-benzyl-5-(m-nitrophenyl)-1-(m-trifluoromethylphenyl)imidazolidine-2,4-dione

: 1366088-52-9
N-cyclohexyl 2-{N-(p-nitrophenylacetyl)-N-[3-(3-benzyl-2,4-dioxo-1-(m-trifluoromethylphenyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: iron; acetic acid / 0.5 h / 50 - 60 °C

2.1: methanol / 0.5 h / Reflux

2.2: Reflux

With iron; acetic acid; In methanol; 2.1: Ugi condensation / 2.2: Ugi condensation;
DOI:10.1016/j.tet.2012.01.073