(+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone

Base Information

• Chemical Name: (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone
• CAS No.: 888325-28-8
• Molecular Formula: C₁₂H₂₂O₄
• Molecular Weight: 230.304
• Mol file: 888325-28-8.mol

Synonyms:(+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone

Chemical Property of (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone

There total 3 articles about (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(+/-)-4-hydroxy-3,3-dimethylcyclohexanone (888325-29-9) + 2-Methoxyethoxymethyl chloride (3970-21-6) → (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone (888325-28-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;

DOI:10.1021/jm060257t

Reference yield:

(+/-)-2,2-dimethyl-4,4-ethylendioxy-1-cyclohexanol (131206-74-1) → (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone (888325-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / aq. hydrochloric acid / acetone / 1 h / Heating

2: 83 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetone;

DOI:10.1021/jm060257t

Reference yield:

4,4-ethylenedioxy-2,2-dimethylcyclohexanone (134409-06-6) → (+/-)-3,3-dimethyl-4-[(2-methoxyethoxy)methoxy]-1-cyclohexanone (888325-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / sodium borohydride / ethanol / 4 h / 20 °C

2: 85 percent / aq. hydrochloric acid / acetone / 1 h / Heating

3: 83 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; acetone;

DOI:10.1021/jm060257t

upstream raw materials:

(+/-)-4-hydroxy-3,3-dimethylcyclohexanone

2-Methoxyethoxymethyl chloride

(+/-)-2,2-dimethyl-4,4-ethylendioxy-1-cyclohexanol

4,4-ethylenedioxy-2,2-dimethylcyclohexanone

Downstream raw materials:

(+/-)-5-((2-methoxyethoxy)methoxy)-2-hydroxy-4,4-dimethylcyclohex-1-enecarboxylic acid methyl ester