131206-74-1Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Page/Page column 75-76, (2018/09/21)
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases
HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS
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Page/Page column 84, (2016/07/05)
The present invention relates to compounds (1) which bind to the NR1 H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds (1) for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Paragraph 0169``, (2015/07/02)
Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites
Gemma, Sandra,Gabellieri, Emanuele,Huleatt, Paul,Fattorusso, Caterina,Borriello, Marianna,Catalanotti, Bruno,Butini, Stefania,De Angelis, Meri,Novellino, Ettore,Nacci, Vito,Belinskaya, Tatyana,Saxena, Ashima,Campiani, Giuseppe
, p. 3421 - 3425 (2007/10/03)
We describe herein the development of novel huperzine A-tacrine hybrids characterized by 3-methylbicyclo-[3.3.1]non-3-ene scaffolds. These compounds were specifically designed to establish tight interactions, through different binding modes, with the midg
