888325-29-9Relevant academic research and scientific papers
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005
Bahmanyar, Sogole,Bennett, Brydon,Blease, Kate,Burnett, Kelven,Cashion, Dan,Cathers, Brian E.,Celeridad, Maria,Chan, Henry,Correa, Matthew,Delgado, Mercedes,Hansen, Joshua,Harris, Roy,Hegde, Sayee,Huang, Dehua,Hur, Eun Mi,Khambatta, Godrej,Khattri, Roli,Kulkarni, Ashutosh,Lebrun, Laurie,Leftheris, Katerina,Liu, Zheng,Morrison, Lisa,Mortensen, Deborah S.,Muir, Jeffrey,Norris, Stephen,Papa, Patrick,Parnes, Jason,Plantevin-Krenitsky, Veronique,Ringheim, Garth,Sapienza, John,Torres, Eduardo,Whitefield, Brandon
supporting information, p. 11886 - 11903 (2021/09/03)
The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines such as
PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS
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Page/Page column 76, (2018/09/21)
The present invention is directed to pyrazole derivatives, pharmaceutical compositions comprising the compounds and the use of the compounds or the compositions in the treatment of various diseases
SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Paragraph 0170, (2015/07/02)
Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites
Gemma, Sandra,Gabellieri, Emanuele,Huleatt, Paul,Fattorusso, Caterina,Borriello, Marianna,Catalanotti, Bruno,Butini, Stefania,De Angelis, Meri,Novellino, Ettore,Nacci, Vito,Belinskaya, Tatyana,Saxena, Ashima,Campiani, Giuseppe
, p. 3421 - 3425 (2007/10/03)
We describe herein the development of novel huperzine A-tacrine hybrids characterized by 3-methylbicyclo-[3.3.1]non-3-ene scaffolds. These compounds were specifically designed to establish tight interactions, through different binding modes, with the midg
