5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester
• CAS No.: 692259-21-5
• Molecular Formula: C₂₁H₂₃ClN₂O₅
• Molecular Weight: 418.877
• Mol file: 692259-21-5.mol

Synonyms:5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester

Chemical Property of 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester

There total 5 articles about 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobenzoylmethyl bromide (536-38-9) → 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester (692259-21-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 1.5 h / 0 - 20 °C

1.2: 95 percent / dimethylformamide / 18 h / 20 °C

2.1: 92 percent / aq. LiOH / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: BTEAC; K₂CO₃ / dimethylformamide / 24 h / 55 °C

4.1: 280 mg / Zn; hydroquinone / tetrahydrofuran / 24 h / Heating

With lithium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; hydroquinone; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Reformatsky-type condensation;

DOI:10.1021/jm031104y

Reference yield:

5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (52867-42-2) → 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester (692259-21-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 1.5 h / 0 - 20 °C

1.2: 95 percent / dimethylformamide / 18 h / 20 °C

2.1: 92 percent / aq. LiOH / tetrahydrofuran; methanol / 1 h / 20 °C

3.1: BTEAC; K₂CO₃ / dimethylformamide / 24 h / 55 °C

4.1: 280 mg / Zn; hydroquinone / tetrahydrofuran / 24 h / Heating

With lithium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; sodium hydride; potassium carbonate; hydroquinone; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4.1: Reformatsky-type condensation;

DOI:10.1021/jm031104y

Reference yield:

5-[2-(4-chlorophenyl)-2-oxoethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (692259-07-7) → 5-[2-(4-chlorophenyl)-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester (692259-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: BTEAC; K₂CO₃ / dimethylformamide / 24 h / 55 °C

2: 280 mg / Zn; hydroquinone / tetrahydrofuran / 24 h / Heating

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; hydroquinone; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Reformatsky-type condensation;

DOI:10.1021/jm031104y

upstream raw materials:

ethyl 2-bromomethyl-2-propenoate

5-[2-(4-chlorophenyl)-2-oxoethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester

4-chlorobenzoylmethyl bromide

5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester

Downstream raw materials:

5-[2-(4-chloro-phenyl)-4-methylene-5-oxo-tetrahydro-furan-2-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid