52867-42-2

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE is used as a building block for the synthesis of bioactive compounds, contributing to the development of new pharmaceuticals due to its chemical properties and reactivity.
Used in Agrochemical Industry:
METHYL 3-HYDROXY-1-METHYLPYRAZOLE-5-CARBOXYLATE is used as an intermediate in the production of pesticides and herbicides, enhancing the effectiveness of these products in agricultural applications.

InChI:InChI=1/C6H8N2O3/c1-8-4(6(10)11-2)3-5(9)7-8/h3H,1-2H3,(H,7,9)

Upstream product

• 58364-79-7 2-(1-Methylhydrazino)maleinsaeure-dimethylester 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 60-34-4 methylhydrazine 
• 302-15-8 methylhydrazine sulfuric acid 
• 22038-72-8 methyldiazene 
• 86625-25-4 methyl 3-hydroxy-1H-pyrazole-5-carboxylate 
• 74-88-4 methyl iodide 
• 123-54-6 acetylacetone 
• 542-92-7 cyclopenta-1,3-diene 

Downstream Products

• 692259-01-1 5-(2-biphenyl-4-yl-2-oxoethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 692258-99-4 2-methyl-5-(2-oxo-2-phenylethoxy)-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-20-5 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-28-3 2-methyl-5-[5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester 
• 1374645-70-1 5-[3-(4-fluoro-phenyl)-5-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1374645-68-7 Methyl 5-[5-(4-fluoro-phenyl)-3-methyl-3H-[1,2,3]triazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylate 
• 1254966-30-7 5-[3-(4-fluoro-phenyl)-5-formyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-33-0 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid 
• 1254965-32-6 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid amide 
• 1254966-32-9 5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254966-38-5 5-[3-butyl-5-(1,2-dihydroxy-2-phenyl-ethyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 1254965-36-0 rac-5-[3-(4-fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid (tetrahydro-furan-3-yl)-amide 
• 1254966-31-8 5-[5-((1S,2R)-1,2-dihydroxy-2-phenyl-ethyl)-3-(4-fluoro-phenyl)-isoxazol-4-ylmethoxy]-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 692259-22-6 5-(2-biphenyl-4-yl-4-methylene-5-oxotetrahydrofuran-2-ylmethoxy)-2-methyl-2H-pyrazole-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

BI-ARYL DIHYDROOROTATE DEHYDROGENASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3, and Q are defined herein.

INDAZOLE CARBOXAMIDES AS KINASE INHIBITORS

Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

Macrocyclic compound serving as ALK and ROS regulators

The invention belongs to the field of medicinal chemistry, and relates to a macrocyclic compound serving as an ALK and ROS regulators, in particular to a compound as shown in a formula I or pharmaceutically acceptable salt thereof, a preparation method, a

Sulfamide-aryl amide type compound and medical application thereof in treatment of hepatitis B

The invention relates to a sulfamide-aryl amide type compound and the medical application thereof in treatment of hepatitis B, and specifically discloses a compound which can be treated as an HBV compound inhibitor and has the structure as shown in chemical formula (A), or a stereisomer, a cis-trans-isomer or a tautomer thereof, or pharmaceutically acceptable salt, aquo-complex or solvent compoundthereof; the identification of each group is shown in the description. The invention also relates to a medical composition containing the abovementioned compound and application thereof in treatmentof hepatitis B.

Compound for treatment on hepatitis B and use thereof

The invention relates to a compound for treatment on hepatitis B and a use thereof. Specifically, the invention discloses a compound as a HBV replication inhibitor having the structure shown in the formula (A), or its stereoisomer, tautomer, pharmaceutically acceptable salt, hydrate or solvate. The groups are detailed in the specification. The invention also relates a pharmaceutical composition containing the compound and a use thereof in treatment on hepatitis B.

POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS

The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

A 3 - (3, 3 - two chlorine alkene-propoxy) - 1 - methyl pyrazole - 5 - carboxamide derivatives and its preparation method

The invention belongs to the pesticide technical field, and particularly relates to 3-(3,3-dichloroallyloxy)-1-methylpyrazole-5-formamide derivatives and a preparation method thereof, and a pesticide composition containing the derivatives. The 3-(3,3-dichloroallyloxy)-1-methylpyrazole-5-formamide derivatives have high bacteriostatic activity, are suitable for prevention and control of plant diseases and virus diseases in the agriculture field, the forestry field and the gardening field, and effectively prevent and control crop diseases and pests.

MACROCYCLIC COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

The compounds and salts of the present invention inhibit kinases, especially the anaplastic lymphoma kinase (ALK) and the HGF receptor tyrosine kinase (RTK) c-Met, and are useful for treating or ameliorating abnormal cell proliferative disorders, such as

AMIDINE SUBSTITUTED BETA - LACTAM COMPOUNDS, THEIR PREPARATION AND USE AS ANTIBACTERIAL AGENTS

The present invention relates to novel β-lactam compounds of formula (I), their preparation and use. In particular, this invention relates to novel β-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.