tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

Base Information

Chemical Name:tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate
CAS No.:1170231-99-8
Molecular Formula:C₂₄H₄₅N₃O₅
Molecular Weight:455.638
Hs Code.:

Synonyms:tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

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Chemical Property of tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

Chemical Property:

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Technology Process of tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

There total 8 articles about tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1170231-18-1
O-cyclohexyl-N-(2-morpholinoethyl)hydroxylamine

: 60142-89-4
7-[(tert-butoxycarbonyl)amino]heptanoic acid

: 1170231-99-8
tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 1170231-46-5
N-cyclohexyl-O-(2-morpholinoethyl)hydroxylamine

: 60142-89-4
7-[(tert-butoxycarbonyl)amino]heptanoic acid

: 1170231-99-8
tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm4009949

Reference yield:

: sodium 6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-hexanesulfonate

: 1170231-99-8
tert-butyl 7-(cyclohexyl(2-morpholinoethoxy)amino)-7-oxoheptylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus pentachloride / toluene

2.1: triethylamine / dichloromethane / 2 h / Cooling with ice

2.2: 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / Cooling with ice

3.2: 19 h / 60 °C

4.1: sodium cyanoborohydride / methanol / Cooling with ice

5.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

With 4-methyl-morpholine; phosphorus pentachloride; sodium hydride; sodium cyanoborohydride; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm4009949