1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

Base Information

Chemical Name:1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone
CAS No.:1357608-67-3
Molecular Formula:C₂₁H₁₅Cl₃F₄N₂O₂
Molecular Weight:509.715
Hs Code.:

Synonyms:1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

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Chemical Property of 1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

Chemical Property:

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Technology Process of 1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

There total 4 articles about 1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1357614-55-1
3-(4-(3-fluoroazetidin-3-yl)phenyl)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

: 75-36-5
acetyl chloride

: 1357608-67-3
1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

Guidance literature:: With pyridine; at 20 ℃; for 1h;

Reference yield:

: 1357614-52-8
3-fluoro-3-(4-formyl-phenyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1357608-67-3
1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride / ethanol; water / 3 h / 20 - 50 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2.2: 72 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.1: pyridine / 1 h / 20 °C

With pyridine; N-chloro-succinimide; hydroxylamine hydrochloride; trifluoroacetic acid; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1357614-54-0
tert-butyl 3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidine-1-carboxylate

: 1357608-67-3
1-(3-fluoro-3-(4-(5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)phenyl)azetidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2: pyridine / 1 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane;