(+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol

Base Information

• Chemical Name: (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol
• CAS No.: 74994-46-0
• Molecular Formula: C₂₃H₃₂O₅
• Molecular Weight: 388.504
• Mol file: 74994-46-0.mol

Synonyms:(+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol

Chemical Property of (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol

There total 9 articles about (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

4-(2,3,4-trimethoxyphenyl)-1-bromobutane (74882-10-3) → C26H38O6 (74882-22-7) + 3-(p-methoxyphenyl)-1-propanol (5406-18-8) + 1-(2,3,4-trimethoxyphenyl)butane (74882-21-6) + (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol (74994-46-0)

Guidance literature:

With 3-(4-methoxyphenyl)propional; magnesium; In tetrahydrofuran;

Reference yield: 16.0%

3-(4-methoxyphenyl)propional (20401-88-1) + 4-(2,3,4-trimethoxyphenyl)-1-bromobutane (74882-10-3) → C26H38O6 (74882-22-7) + 3-(p-methoxyphenyl)-1-propanol (5406-18-8) + 1-(2,3,4-trimethoxyphenyl)butane (74882-21-6) + (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol (74994-46-0)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield:

1,2,3-trimethoxybenzene (634-36-6) → (+/-)-1-(4-methoxyphenyl)-7-(2,3,4-trimethoxyphenyl)heptan-3-ol (74994-46-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) aluminium chloride, 2.) sodium dithionite, sodium hydroxide / 1.) 1,1,2,2-tetrachloroethane, room temperature, 16 h; steam-bath, 2 h, 2.) methanol, room temperature, 21 h, reflux, 24 h

2: 88 percent / hydrogen / palladium-carbon / acetic acid / 1.5 h / Ambient temperature

3: 59 percent / lithium aluminium hydride / diethyl ether

4: 62 percent / pyridine

5: 80 percent / lithium bromide / acetone / 24 h / Ambient temperature

6: 16 percent / magnesium (from magnesium chloride and potassium metal) / tetrahydrofuran

With pyridine; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; sodium dithionite; hydrogen; magnesium; lithium bromide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; acetic acid; acetone;

upstream raw materials:

3-(4-methoxyphenyl)propional

4-(2,3,4-trimethoxyphenyl)-1-bromobutane

1,2,3-trimethoxybenzene

3-(p-methoxyphenyl)-1-propanol

Downstream raw materials:

Acetic acid 1-[2-(4-methoxy-phenyl)-ethyl]-5-(2,3,4-trimethoxy-phenyl)-pentyl ester

1-(4-methoxyphenyl)-7-(2,3,4-trimethoxy-5-iodophenyl)heptan-3-ol

1-(3-iodo-4-methoxyphenyl)-7-(5-iodo-2,3,4-trimethoxyphenyl)heptan-3-ol

1-(4-Methoxy-phenyl)-7-(2,3,4-trimethoxy-phenyl)-heptan-3-one