74882-21-6

Basic information

• Product Name: 1-(2,3,4-trimethoxyphenyl)butane
• Synonyms: 1-(2,3,4-trimethoxyphenyl)butane
• CAS NO: 74882-21-6
• Molecular Weight: 224.3
• Mol File: 74882-21-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2,3,4-trimethoxyphenyl)butane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,3,4-trimethoxyphenyl)butane(74882-21-6)
• EPA Substance Registry System: 1-(2,3,4-trimethoxyphenyl)butane(74882-21-6)

Safety Data

• Hazardous Substances Data: 74882-21-6(Hazardous Substances Data)

Upstream product

• 25245-37-8 1-iodo-2,3,4-trimethoxy-benzene 
• 109-69-3 n-Butyl chloride 
• 51686-51-2 methyl 4-(2,3,4-trimethoxyphenyl)butanoate 
• 634-36-6 1,2,3-trimethoxybenzene 
• 74882-10-3 4-(2,3,4-trimethoxyphenyl)-1-bromobutane 
• 51686-50-1 methyl 3-(2,3,4-trimethoxybenzoyl)propionate 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 74882-11-4 Toluene-4-sulfonic acid 4-(2,3,4-trimethoxy-phenyl)-butyl ester 
• 74882-09-0 4-(2,3,4-trimethoxyphenyl)butan-1-ol 

Relevant articles and documents

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generatedviaC(sp3)-H activation

Transition-metal-catalyzed cross-electrophile C(sp2)-(sp3) coupling and C-H alkylation reactions represent two efficient methods for the incorporation of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides. Methoxy and benzyloxy groups, which are ubiquitous functional groups and common protecting groups, were utilized as crucial mediatorsviaprimary or secondary C(sp3)-H activation. The reaction provides an innovative and convenient access for the synthesis of alkylated phenol derivatives, which are widely found in bioactive compounds and organic functional materials.