N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Base Information

Chemical Name:N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide
CAS No.:1415798-17-2
Molecular Formula:C₃₀H₁₈F₂N₆O₃S₂
Molecular Weight:612.64
Hs Code.:

N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Synonyms:N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Chemical Property of N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

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Technology Process of N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

There total 9 articles about N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 875340-09-3
3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thienthio[3,2-b]pyridine-7-oxy)aniline

: C₁₃H₆ClFN₂O₂S

: 1415798-17-2
N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1415797-71-5
4-(4-fluorophenyl)-6-(methoxycarbonyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-7-oxy sodium salt

: 1415798-17-2
N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 5 steps

1: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; triethylsilane; triethylamine / 3 h / 80 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

4: thionyl chloride / toluene / 2 h / 20 °C

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; lithium hydroxide monohydrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1415797-72-6
ethyl 5-(N-(4-fluorophenyl)-2-methoxycarbonylacetamido)thiazole-4-formate

: 1415798-17-2
N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thiophene[3,2-b]pyridine-7-oxy)phenyl)-4-(4-fluorophenyl)-5-oxo-4,5-dihydrothiazolo[5,4-b]pyridine-6-formamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / methanol / 20 °C

2: N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: bis-triphenylphosphine-palladium(II) chloride; triethylsilane; triethylamine / 3 h / 80 °C

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 0.5 h / 20 °C

5: thionyl chloride / toluene / 2 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

With triethylsilane; bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; lithium hydroxide monohydrate; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene;