(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

Base Information

Chemical Name:(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine
CAS No.:1290176-65-6
Molecular Formula:C₂₆H₂₁N₃O₆
Molecular Weight:471.469
Hs Code.:

Synonyms:(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

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Chemical Property of (3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

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Technology Process of (3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

There total 4 articles about (3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (S)-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine

: 3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl chloride

: 1290176-65-6
(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

Guidance literature:: In dichloromethane; at 20 ℃; for 6h; optical yield given as %de;
DOI:10.1016/j.tetasy.2010.12.017

Reference yield:

: 32329-20-7,113708-92-2
(RS)-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine

: 3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl chloride

: (3R)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-N-phthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

: 1290176-65-6
(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

: 200125-70-8
(S)-2-methyl-1,2,3,4-tetrahydroquinoline

: 1780-19-4,63430-95-5,74497-74-8
(R)-1,2,3,4-tetrahydroquinaldine

Guidance literature:: In dichloromethane; at -20 ℃; for 6h; optical yield given as %ee; stereoselective reaction;
DOI:10.1016/j.tetasy.2010.12.017

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 1290176-65-6
(3S)-2,3-dihydro-3-methyl-4-[3-(4-nitrophenyl)-nphthaloyl-(S)-alanyl]-4H-1,4-benzoxazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water / 20 °C

2: oxalyl dichloride / hexane; N,N-dimethyl-formamide; benzene / 6 h / 20 °C

3: dichloromethane / 6 h / 20 °C

With oxalyl dichloride; sodium carbonate; In hexane; dichloromethane; water; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetasy.2010.12.017