17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol

Base Information

• Chemical Name: 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol
• CAS No.: 90850-54-7
• Molecular Formula: C₂₇H₂₉F₅O₄
• Molecular Weight: 512.517
• Mol file: 90850-54-7.mol

Synonyms:17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol

Chemical Property of 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol

There total 3 articles about 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

sodium methylate (124-41-4) + 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene (90850-50-3) → 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol (90850-54-7)

Guidance literature:

In N,N-dimethyl-formamide; at 10 ℃; for 1h;

DOI:10.1039/c39840000125

Reference yield: 68.0%

sodium methylate (124-41-4) + 3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene (90850-50-3) → estradiol (50-28-2) + 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol (90850-54-7)

Guidance literature:

In N,N-dimethyl-formamide; at 10 ℃; for 2h;

Reference yield:

estradiol (50-28-2) → 17β-<2,6-difluoro-3,5-dimethoxy-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-trien-3-ol (90850-54-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Bu₄NHSO₄, 2M NaOH / CH₂Cl₂; H₂O / 16 h / Ambient temperature

2: 68 percent / dimethylformamide / 2 h / 10 °C

With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; N,N-dimethyl-formamide;

upstream raw materials:

sodium methylate

3,17β-di-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>estra-1,3,5(10)-triene

estradiol

Downstream raw materials:

estradiol