(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

Base Information

Chemical Name:(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid
CAS No.:1315472-13-9
Molecular Formula:C₂₆H₂₃FN₄O₆
Molecular Weight:506.49
Hs Code.:

Synonyms:(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

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Chemical Property of (S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

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Technology Process of (S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

There total 9 articles about (S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₁FN₄O₆

: 1315472-13-9
(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 2h;

Reference yield:

: 1315457-41-0
5-(2-fluoro-phenoxy)-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine

: 1315472-13-9
(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / 2.17 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

3: trifluoroacetic acid / 20 °C

4: thionyl chloride / 48 h

5: triethylamine / dichloromethane / 2 h

6: trifluoroacetic acid / 2 h / 20 °C

With thionyl chloride; boron tribromide; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1315457-42-1
4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

: 1315472-13-9
(S)-1-(2-{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetyl)-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2: trifluoroacetic acid / 20 °C

3: thionyl chloride / 48 h

4: triethylamine / dichloromethane / 2 h

5: trifluoroacetic acid / 2 h / 20 °C

With thionyl chloride; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;