{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Base Information

Chemical Name:{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid
CAS No.:1315311-12-6
Molecular Formula:C₂₁H₁₆FN₃O₅
Molecular Weight:409.374
Hs Code.:

Synonyms:{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

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Chemical Property of {4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

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Technology Process of {4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

There total 6 articles about {4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₄FN₃O₅

: 1315311-12-6
{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: With trifluoroacetic acid; at 20 ℃;

Reference yield:

: 1315312-36-7
5-chloro-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine

: 1315311-12-6
{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 1.5 h / 20 °C

2.1: boron tribromide / dichloromethane / 2.17 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

4.1: trifluoroacetic acid / 20 °C

With boron tribromide; sodium hydride; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 1315457-41-0
5-(2-fluoro-phenoxy)-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine

: 1315311-12-6
{4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 2.17 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

3: trifluoroacetic acid / 20 °C

With boron tribromide; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;