2-(4-methylphenyl)propanoic acid ethyl ester

Base Information

• Chemical Name: 2-(4-methylphenyl)propanoic acid ethyl ester
• CAS No.: 78926-01-9
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.258
• Mol file: 78926-01-9.mol

Synonyms:2-(4-methylphenyl)propanoic acid ethyl ester

Chemical Property of 2-(4-methylphenyl)propanoic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methylphenyl)propanoic acid ethyl ester

There total 16 articles about 2-(4-methylphenyl)propanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + (R,S)-2-(4'-methylphenyl) propionic acid (938-94-3) → 2-(4-methylphenyl)propanoic acid ethyl ester (78926-01-9)

Guidance literature:

With toluene-4-sulfonic acid; for 12h; Heating;

DOI:10.1002/jlcr.1105

Reference yield: 90.0%

2-(4-methylphenyl)propenoic acid ethyl ester (128839-68-9) → 2-(4-methylphenyl)propanoic acid ethyl ester (78926-01-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 4h; under 2327.23 Torr;

DOI:10.1002/hlca.201500062

Reference yield: 86.0%

p-tolylacetic acid ethyl ester (14062-19-2) + methyl iodide (74-88-4) → 2-(4-methylphenyl)propanoic acid ethyl ester (78926-01-9)

Guidance literature:

p-tolylacetic acid ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -40 ℃; for 1h;

methyl iodide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; n-heptane; ethylbenzene; at -40 - 20 ℃;

DOI:10.1021/jm040006p

upstream raw materials:

ethyl 2-acetoxy-2-p-tolylpropionate

α-chloro-4-methyl propiophenone

orthoformic acid triethyl ester

p-tolylacetic acid ethyl ester

Downstream raw materials:

(R,S)-2-(4'-methylphenyl) propionic acid

(S)-(+)-2-(4'-methylphenyl)propanoic acid

ethyl 6-bromo-2-methyl-2-p-tolylhexanoate

methyl 2-deuterio-2-tolylpropionate

Refernces

• 1、 Chen, Tiffany Q.,MacMillan, David W. C.. "A Metallaphotoredox Strategy for the Cross-Electrophile Coupling of α-Chloro Carbonyls with Aryl Halides". supporting information. p. 14584 - 14588. Retrieved 2019/09/17.
• 2、 Shahid Islam,Ahmad, Syarhabil,Attu, Mary Rose,Foerstering, F. Holger,Mahmun Hossain. "Concise Synthesis of 2-Arylpropanoic Acids and Study of Unprecedented Reduction of 3-Hydroxy-2-arylpropenoic Acid Ethyl Ester to 2-Arylpropenoic Acid Ethyl Ester by BH3·THF". . p. 1273 - 1286. Retrieved 2015/09/22.