(+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol

Base Information

• Chemical Name: (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol
• CAS No.: 168125-51-7
• Molecular Formula: C₁₃H₂₁FO₄SSi
• Molecular Weight: 320.457
• Mol file: 168125-51-7.mol

Synonyms:(+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol

Chemical Property of (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol

There total 4 articles about (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

methanesulfonyl chloride (124-63-0) + (+)-2-(4-fluorophenyl)-3-trimethylsilylpropan-1,2-diol (168125-50-6) → (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol (168125-51-7)

Guidance literature:

With pyridine; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2004.04.027

Reference yield:

2-(4-fluorophenyl)-2-oxoacetic acid (2251-76-5) → (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol (168125-51-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl chloride / CH₂Cl₂ / 3 h / 20 °C

1.2: 88 percent / acetonitrile / 3 h / 20 °C

2.1: 63 percent / diethyl ether / 1 h / -70 °C

3.1: 43 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4.1: 84 percent / pyridine / 2 h / 0 °C

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; 2.1: Grignard reaction;

DOI:10.1016/j.bmc.2004.04.027

Reference yield:

2-phenylcyclohexyl 2-(4-fluorophenyl)glyoxylate (820225-71-6) → (+)-2-(4-fluorophenyl)-1-methanesulfonyloxy-3-trimethylsilylpropan-2-ol (168125-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 63 percent / diethyl ether / 1 h / -70 °C

2: 43 percent / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: 84 percent / pyridine / 2 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; 1: Grignard reaction;

DOI:10.1016/j.bmc.2004.04.027

upstream raw materials:

methanesulfonyl chloride

(+)-2-(4-fluorophenyl)-3-trimethylsilylpropan-1,2-diol

2-(4-fluorophenyl)-2-oxoacetic acid

2-phenylcyclohexyl 2-(4-fluorophenyl)glyoxylate