tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Chemical Name:tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate
CAS No.:1439397-39-3
Molecular Formula:C₂₈H₂₉ClN₄O₂
Molecular Weight:489.017
Hs Code.:

Synonyms:tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

There total 5 articles about tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1032528-06-5
{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert.-butyl ester

: 1439397-37-1
2-chloro-7-iodo-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidine

: 1439397-39-3
tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Inert atmosphere;

Reference yield:

: 536-74-3
phenylacetylene

: 1439397-39-3
tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 100 °C / Inert atmosphere

2.1: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride / ethyl acetate / Inert atmosphere; Reflux

4.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; iodine; caesium carbonate; triethylamine; potassium hydroxide; XPhos; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1439396-27-6
5-bromo-2-chloro-4-(phenylethynyl)pyrimidine

: 1439397-39-3
tert-butyl 1-(4-(2-chloro-5-methyl-6-phenyl-5H-pyrrolo[3,2-d]pyrimidin-7-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate / Inert atmosphere; Reflux

3.1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; iodine; caesium carbonate; potassium hydroxide; XPhos; In 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide;