1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

Base Information

Chemical Name:1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole
CAS No.:131372-36-6
Molecular Formula:C₃₀H₃₄N₂O₇SSi
Molecular Weight:594.761
Hs Code.:

Synonyms:1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

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Chemical Property of 1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

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Technology Process of 1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

There total 5 articles about 1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 131372-35-5
1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

: 124-63-0
methanesulfonyl chloride

: 131372-36-6
1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

Guidance literature:: With pyridine; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1055/s-1990-27062

Reference yield:

: 4769-97-5
4-nitro-1H-indoIe

: 131372-36-6
1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) KOH, tris<2-(2-methoxyethoxy)ethyl>amine / 1.) MeCN, room temperature, 15 min, 2.) room temperature, 15 min

2: 8 percent / NaOMe, MeOH / 6 h / Ambient temperature

3: 65 percent / pyridine / 24 h / Ambient temperature

4: 91 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; methanol; potassium hydroxide; Tris(3,6-dioxaheptyl)amine; sodium methylate; In dichloromethane;
DOI:10.1055/s-1990-27062

Reference yield:

: 118452-17-8
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-nitro-1H-indole

: 131372-36-6
1-<2-Deoxy-5-O-(tert-butyldiphenylsilyl)-3-O-mesyl-β-D-erythro-pentofuranosyl>-4-nitro-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / 24 h / Ambient temperature

2: 91 percent / pyridine / CH₂Cl₂ / 4 h / Ambient temperature

With pyridine; In dichloromethane;
DOI:10.1055/s-1990-27062