3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

Base Information

Chemical Name:3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid
CAS No.:939378-06-0
Molecular Formula:C₃₃H₄₅N₂O₆P
Molecular Weight:596.704
Hs Code.:

Synonyms:3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

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Chemical Property of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

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Technology Process of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

There total 5 articles about 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 939377-98-7
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid

: 591-50-4
iodobenzene

: 939378-06-0
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

Guidance literature:: With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 65 ℃; for 48h;
DOI:10.1016/j.bmc.2007.02.042

Reference yield:

: 939378-02-6
2-benzyloxycarbonylamino-3-[(1-tert-butyloxycarbonylamino-3-phenylpropyl)hydroxyphosphinoyl]propionic acid methyl ester

: 939378-06-0
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / silver oxide / CHCl₃ / Heating

2: 92 percent / aq. NaOH / methanol / 16 h / 20 °C

3: 100 percent / H₂ / Pd/BaSO₄ / methanol; H₂O / 3.5 h

4: 22 percent / CuI; K₂CO₃ / dimethylsulfoxide / 48 h / 65 °C

With sodium hydroxide; copper(l) iodide; hydrogen; potassium carbonate; silver(l) oxide; Pd-BaSO₄; In methanol; chloroform; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2007.02.042

Reference yield:

: C₃₅H₄₇N₂O₈P

: 939378-06-0
3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / H₂ / Pd/BaSO₄ / methanol; H₂O / 3.5 h

2: 22 percent / CuI; K₂CO₃ / dimethylsulfoxide / 48 h / 65 °C

With copper(l) iodide; hydrogen; potassium carbonate; Pd-BaSO₄; In methanol; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2007.02.042