3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid

Base Information

• Chemical Name: 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid
• CAS No.: 939377-98-7
• Molecular Formula: C₂₇H₄₁N₂O₆P
• Molecular Weight: 520.606
• Mol file: 939377-98-7.mol

Synonyms:3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid

Chemical Property of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid

There total 4 articles about 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C35H47N2O8P → 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid (939377-98-7)

Guidance literature:

With hydrogen; Pd-BaSO₄; In methanol; water; for 3.5h;

DOI:10.1016/j.bmc.2007.02.042

Reference yield:

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzyloxycarbonylaminopropionic acid methyl ester (939378-04-8) → 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid (939377-98-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / aq. NaOH / methanol / 16 h / 20 °C

2: 100 percent / H₂ / Pd/BaSO₄ / methanol; H₂O / 3.5 h

With sodium hydroxide; hydrogen; Pd-BaSO₄; In methanol; water;

DOI:10.1016/j.bmc.2007.02.042

Reference yield:

2-benzyloxycarbonylamino-3-[(1-tert-butyloxycarbonylamino-3-phenylpropyl)hydroxyphosphinoyl]propionic acid methyl ester (939378-02-6) → 3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-aminopropionic acid (939377-98-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / silver oxide / CHCl₃ / Heating

2: 92 percent / aq. NaOH / methanol / 16 h / 20 °C

3: 100 percent / H₂ / Pd/BaSO₄ / methanol; H₂O / 3.5 h

With sodium hydroxide; hydrogen; silver(l) oxide; Pd-BaSO₄; In methanol; chloroform; water;

DOI:10.1016/j.bmc.2007.02.042

upstream raw materials:

2-benzyloxycarbonylamino-3-[(1-tert-butyloxycarbonylamino-3-phenylpropyl)hydroxyphosphinoyl]propionic acid methyl ester

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-benzyloxycarbonylaminopropionic acid methyl ester

(1-(N-(tert-butyloxycarbonyl)amino)-3-phenylpropyl) phosphinic acid

Downstream raw materials:

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-(4-hydroxymethylphenylamino)propionic acid

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-[4-(tert-butyloxycarbonylaminomethyl)phenylamino]propionic acid

3-[(adamantan-1-yloxy)-(1-tert-butyloxycarbonylamino-3-phenylpropyl)phosphinoyl]-2-phenylaminopropionic acid