2,6-difluorophenyl sulfamate

Base Information

• Chemical Name: 2,6-difluorophenyl sulfamate
• CAS No.: 1186393-80-5
• Molecular Formula: C₆H₅F₂NO₃S
• Molecular Weight: 209.173
• Mol file: 1186393-80-5.mol

Synonyms:2,6-difluorophenyl sulfamate

Chemical Property of 2,6-difluorophenyl sulfamate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,6-difluorophenyl sulfamate

There total 1 articles about 2,6-difluorophenyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-difluorophenol (28177-48-2) → 2,6-difluorophenyl sulfamate (1186393-80-5)

Guidance literature:

With formic acid; isocyanate de chlorosulfonyle; In 1-methyl-pyrrolidin-2-one; acetonitrile; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04119

Reference yield: 86.4%

2,6-difluorophenyl sulfamate (1186393-80-5) + C18H25BrN2O4Si → C24H29F2N3O7SSi

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; silver trifluoromethanesulfonate; In dichloromethane; at 22 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.7b09929

Reference yield: 86.0%

1-trifluoromethyl-4-vinyl-benzene (402-50-6) + 2,6-difluorophenyl sulfamate (1186393-80-5) → C15H10F5NO3S

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; [bis(acetoxy)iodo]benzene; magnesium oxide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1055/s-0037-1609858

upstream raw materials:

2,6-difluorophenol