1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene

Base Information

• Chemical Name: 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene
• CAS No.: 288268-44-0
• Molecular Formula: C₂₀H₂₈O₈
• Molecular Weight: 396.438
• Mol file: 288268-44-0.mol

Synonyms:1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene

Chemical Property of 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene

There total 9 articles about 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-(1'-hydroxy-ethyl)-2,5-di-tert-butoxycarbonyloxy-benzene (288268-43-9) + acetyl chloride (75-36-5) → 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene (288268-44-0)

Guidance literature:

1-(1'-hydroxy-ethyl)-2,5-di-tert-butoxycarbonyloxy-benzene; With methyllithium; at -78 ℃; for 0.5h;

acetyl chloride; Further stages.;

DOI:10.1021/ja994209s

Reference yield: 75.0%

methyllithium (917-54-4) + acetyl chloride (75-36-5) + bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde (288268-32-6) → 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene (288268-44-0)

Guidance literature:

methyllithium; bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde; at -78 ℃; for 0.5h;

acetyl chloride; Further stages.;

DOI:10.1021/ja994209s

Reference yield: 71.0%

acetyl chloride (75-36-5) + bis-(2,4-tert-butoxycarbonyloxy)-acetophenone (288268-31-5) → 1-(1'-tert-butoxycarbonyloxy-ethyl)-2-acetoxy-5-tert-butoxycarbonyloxy-benzene (288268-44-0)

Guidance literature:

bis-(2,4-tert-butoxycarbonyloxy)-acetophenone; With methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.583333h;

acetyl chloride; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ja994209s

upstream raw materials:

acetyl chloride

1-(1'-hydroxy-ethyl)-2,5-di-tert-butoxycarbonyloxy-benzene

methyllithium

bis-(2,4-tert-butoxycarbonyloxy)-benzaldehyde