(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Base Information

Chemical Name:(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine
CAS No.:1572928-17-6
Molecular Formula:C₁₅H₂₁N₃OS
Molecular Weight:291.417
Hs Code.:

Synonyms:(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

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Chemical Property of (2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Chemical Property:

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Technology Process of (2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

There total 10 articles about (2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572928-16-5
benzyl (3S)-4-(4-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1572928-17-6
(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: With sulfuric acid; In chloroform; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 104-95-0
(4-bromophenyl)thioanisole

: 1572928-17-6
(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; acetic acid / water / 0 - 20 °C

2.1: sodium azide / chloroform / 20 °C

2.2: 0 - 20 °C

3.1: formic acid; sulfuric acid / water / 36 h / 20 - 100 °C

4.1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

5.1: sulfuric acid / chloroform / 1 h / 20 °C / Cooling with ice

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formic acid; sodium azide; sulfuric acid; dihydrogen peroxide; acetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; chloroform; water;

Reference yield:

: 934-71-4
1-bromo-4-(methylsulfinyl)benzene

: 1572928-17-6
(2S)-1-(4-(N,S-dimethylsulfonimidoyl)phenyl)-2-(1-propyn-1-yl)piperazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / chloroform / 20 °C

1.2: 0 - 20 °C

2.1: formic acid; sulfuric acid / water / 36 h / 20 - 100 °C

3.1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

4.1: sulfuric acid / chloroform / 1 h / 20 °C / Cooling with ice

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; formic acid; sodium azide; sulfuric acid; johnphos; sodium t-butanolate; In 1,4-dioxane; chloroform; water;