934-71-4

Usage

Uses

Used in Pharmaceutical Industry:
1-BROMO-4-(METHYLSULPHINYL)BENZENE 97 is used as an intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and enhance the properties of existing ones.
Used in Agrochemical Industry:
1-BROMO-4-(METHYLSULPHINYL)BENZENE 97 is used as an intermediate in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Organic Synthesis:
1-BROMO-4-(METHYLSULPHINYL)BENZENE 97 is used as a key component in organic synthesis, enabling the creation of a wide range of chemical compounds for various applications.
Used in Dye and Pigment Production:
1-BROMO-4-(METHYLSULPHINYL)BENZENE 97 is used in the production of dyes and pigments, providing color and enhancing the properties of these products.

InChI:InChI=1/C7H7BrOS/c1-10(9)7-4-2-6(8)3-5-7/h2-5H,1H3

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 104-95-0 (4-bromophenyl)thioanisole 
• 7697-37-2 nitric acid 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 145166-15-0 (S)-methyl p-bromophenyl sulfoxide 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 108-98-5 thiophenol 
• 3996-48-3 p-bromophenylsulfinylacetic acid 
• 3406-76-6 (4-bromophenylthio)acetic acid 
• 67-68-5 dimethyl sulfoxide 
• 106-53-6 para-bromobenzenethiol 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 143307-87-3 para-methylsulfinyl α,β,β-trifluorostyrene 
• 3466-32-8 4-bromoohenyl methyl sulfone 
• 67833-42-5 1-bromo-4-(chloromethylsulfonyl)benzene 
• 202146-93-8 (4-Methanesulfinyl-phenyl)-p-tolyl-amine 
• 202146-94-9 4-methylsulfinylphenyl(phenyl)amine 
• 28227-62-5 (R)-1-bromo-4-(methylsulfinyl)benzene 
• 3079-28-5 decyl methyl sulfoxide 
• 104-95-0 (4-bromophenyl)thioanisole 
• 272770-06-6 Trifluoro-acetic acid 4-bromo-phenylsulfanylmethyl ester 
• 381723-20-2 C₃₁H₂₈N₄OS 
• 145026-07-9 1-bromo-4-(S-methylsulfonimidoyl)benzene 
• 145166-15-0 (S)-methyl p-bromophenyl sulfoxide 
• 420835-80-9 (4-iodophenyl)-(4-methylsulfinylphenyl)amine 
• 420835-85-4 (4-methylsulfinylphenyl)(4-phenylthiophenyl)amine 

Relevant academic research and scientific papers

Charge Transfer from Donor to Acceptor in Conjugated Microporous Polymer for Enhanced Photosensitization

Photosensitization associated with light absorption and energy/electron-transfer represents the central processes for photosynthesis. However, it's still a challenge to develop a heavy-atom-free (HAF) strategy to improve the sensitizing ability of polymeric photosensitizers. Herein, we propose a new protocol to significantly improve the photosensitization by decorating mother conjugated microporous polymer (CMP-1) with polycyclic aromatic hydrocarbons (PAHs), resulting in a series of CMPs (CMP-2–4). Systematic study reveals that covalent modification with PAHs can transfer charge to Bodipy in CMP to further facilitate both intersystem crossing and electron-hole separation, which can dramatically boost energy-/electron-transfer reactions. Remarkably, CMP-2 as a representative CMP can efficiently drive the photosynthesis of methyl phenyl sulfoxide with 92 % yield, substantially higher than that of CMP-1 (32 %). Experiments and theory calculations demonstrate the structure-property-activity relationship of these CMPs, opening a new horizon for developing HAF heterogeneous photosensitizers with highly efficient sensitizing activity by rational structure regulation at a molecular level.

Deep eutectic solvent-assisted synthesis of highly efficient nanocatalyst (n-TiO2@TDI@DES (ZnCl2:urea)) for chemoselective oxidation of sulfides to sulfoxides

This study proposed a straightforward process to synthesize 2,4-toluene diisocyanate (TDI)-functionalized TiO2 nanoparticles in which a cost-effective linker (TDI) with high reactivity was employed to couple nano-TiO2 through covalent bonding to a deep eutectic solvent (DES). By this method, DES was successfully immobilized on the TiO2@TDI surface as an adsorbent and stabilizer. The structural, morphological, and physicochemical characteristics of the synthesized nanocatalysts were evaluated using various analytical methods including Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM–EDX), and elemental analysis. The heterogeneity of the catalyst was also examined by a hot filtration test. The obtained TiO2@TDI@DES nanoparticles offered superior catalytic behavior and excellent yield as well as recyclability for the chemoselective oxidation of sulfide into sulfoxide using a green oxidant (hydrogen peroxide). This catalyst exhibited excellent reusability as it can be recovered for six successive cycles with no significant leach or reduction of catalytic efficiency.

Catalyst-free visible light-mediated selective oxidation of sulfides into sulfoxides under clean conditions

A facile and efficient visible-light-mediated method for directly converting sulfides into sulfoxides under clean conditions without using any photocatalysts is reported. This method exhibited favourable compatibility with functional groups and afforded a series of sulfoxides with high selectivity and yields. Moreover, in order to shed more light on such a transformation, detailed mechanism studies were carried out both experimentally and theoretically. The readily accessible, low-cost and eco-friendly nature of the developed method will endow it with attractive applications in chemical synthesis.

Selective Photocatalytic Oxidation of Sulfides in Lanthanide Metal -Organic Frameworks Incorporating Ru(2,2′-bpy)3 photosensitizer

Three isostructural lanthanide metal-organic frameworks (Ln-MOFs) were synthesized with uncoordinated N^N site, and the Ru(N^N)3 photosensitizer was introduced via coordination link. These functionalized frameworks showed excellent performance

Integrating hydrogen production with anodic selective oxidation of sulfides over a CoFe layered double hydroxide electrode

Replacing the sluggish oxygen evolution reaction (OER) with oxidation reactions for the synthesis of complex pharmaceutical molecules coupled with enhanced hydrogen evolution reaction (HER) is highly attractive, but it is rarely explored. Here, we report an electrochemical protocol for selective oxidation of sulfides to sulfoxides over a CoFe layered double hydroxide (CoFe-LDH) anode in an aqueous-MeCN electrolyte, coupled with 2-fold promoted cathodic H2productivity. This protocol displays high activity (85-96% yields), catalyst stability (10 cycles), and generality (12 examples) in selective sulfide oxidation. We demonstrate its applicability in the synthesis of four important pharmaceutical related sulfoxide compounds with scalability (up to 1.79 g). X-ray spectroscopy investigations reveal that the CoFe-LDH material evolved into amorphous CoFe-oxyhydroxide under catalytic conditions. This work may pave the way towards sustainable organic synthesis of valuable pharmaceuticals coupled with H2production.

SSAO INHIBITORS AND USE THEREOF

Provided are a compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, a pharmaceutical composition comprising a compound of formula (I') or (I), and a method of treating or preventing a disease in which SSAO plays a role.

g-C3N4/H3PW4Mo8O40 S-scheme photocatalyst with enhanced photocatalytic oxidation of alcohols and sulfides

In this work, graphitic carbon nitride (g-C3N4) decorated with molybdenum-substituted tungstophosphoric acid as a novel photocatalyst (H3PW4Mo8O40/g-C3N4) was used to catalyze the oxidation of alcohols and sulfides. H3PW4Mo8O40/g-C3N4 (PW4Mo8/g-C3N4) displays higher photocatalytic activity under visible light irradiation for the oxidation of alcohols and sulfides compared with Keggin/g-C3N4 (PW12/g-C3N4). To obtain the optimum value, molybdenum substitution contents (H3PW12-xMoxO40) were changed from x = 4 to 12. The results showed that PW4Mo8 produces the best yield under visible-light irradiation. The results showed that PW4Mo8 was the best sample. The reaction rate increase can be due to the redox and acid properties of PW4Mo8/g-C3N4. This study provides a new insight for the preparation of highly efficient photocatalysts for the oxidation of organic compounds.

Synergistic cooperative effect of CF3SO2Na and bis(2-butoxyethyl)ether towards selective oxygenation of sulfides with molecular oxygen under visible-light irradiation

A safe, practical and eco-friendly method for the switchable synthesis of sulfoxides and sulfones through visible-light-initiated oxygenation of sulfides at ambient temperature under transition-metal-, additives-free and minimal solvent conditions. The synergistic catalytic efforts between CF3SO2Na and 2-butoxyethyl ether represents the key promoting factor for the reaction. This journal is

Organocatalytic sulfoxidation

Treatment of a sulfide with a catalytic amount of a 1,3-diketone in the presence of silica sulfuric acid as a co-catalyst and hydrogen peroxide (50% aq) as the stoichiometric oxidant leads to the corresponding sulfoxide product. The reaction is effective for diaryl, aryl-alkyl and dialkyl sulfides and is tolerant of oxidisable and acid sensitive functional groups. Investigations have shown that the tris-peroxide 2, formed on reaction of pentane-2,4-dione with hydrogen peroxide under acidic reaction conditions, can oxidise two equivalents of sulfide using the exocyclic peroxide groups whereas the endocyclic peroxide remains intact. Calculations provide a mechanism consistent with experimental observations and suggest the reaction proceeds via an initial acid catalysed ring opening of a protonated tris-peroxide prior to oxygen transfer to a sulfur nucleophile.

Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes

An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides toN-cyanosulfoximines has been developed. In total, 69 examples of sulfoxides, sulfones, andN-cyanosulfoximines have been synthesized in good to excellent yields and with high current efficiencies. The synthesis was assisted and facilitated through a supporting electrolyte-free, fully automated electrochemical protocol that highlights the advantages of flow electrolysis.